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KMID : 1007520220310131703
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Food Science and Biotechnology
2022 Volume.31 No. 13 p.1703 ~ p.1715
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In vivo functional effects of Weissella confusa VP30 exopolysaccharides on loperamide-induced constipation in rats
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Park Se-Ho
Lee Mi-Ra
Yang Su-Young
Lee Ju-Yeon
Lee Hyun-Ha
Seong Yeong-Je
Kim Bo-Hye
Kim Hee-Jun
Jin Hui
Johnston Tony V.
Ku Seock-Mo
Park Myeong-Soo
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Abstract
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In this work, the in vivo functionalities of milk fermented with Weissella confusa VP30 (VP30-EPS) and purified exopolysaccharide (pEPS) from the milk fermented with Weissella confusa VP30 were evaluated for their effect on constipation using an experimental constipated rat model. Rats were randomly divided into four groups: (i) control group (PBS administered normal group), (ii) loperamide treated group (constipation group), (iii) constipation with loperamide plus VP30-EPS (1 g/kg), and (iv) constipation with loperamide plus pEPS (0.6 g/kg) groups. Loperamide treatment induced animal constipation and significantly reduced the frequency of defecation, intestinal transit ratio, and water content of feces. However, all four fecal parameters were improved in both the loperamide plus VP30-EPS and pEPS administered groups as compared to the loperamide group. These results suggest that the addition of VP30-EPS potentially improves the functional laxative effects of commercial products. This study suggests the possibility that VP30-EPS can be applied to fermented and/or functional foods to relieve constipation.
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KEYWORD
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Constipation, Exopolysaccharide, Fecal water content, Water holding capacity, Weissella confusa VP30
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